What Is Somatic Testing?
Somatic testing is a type of molecular profiling that looks at the tumor’s DNA for specific genetic mutations and biomarkers. Unlike inherited genetic mutations, somatic mutations are acquired and only found in the tumor tissue. For pancreatic cancer patients, this testing gives us key insights to shape personalized treatment strategies. It’s about making decisions based on what’s actually going on in your body (National Cancer Institute).
Breaking Down the Jargon
Cancer diagnostics can feel overwhelming. Let’s make sense of some of these common terms:
Molecular Profiling vs. Genomic Testing
These terms often get used interchangeably, but there’s a small difference. Genomic testing can sometimes mean a broader analysis that includes non-coding regions of the genome, giving a more complete picture of potential changes (Nature Reviews Cancer).
Biomarkers
Think of biomarkers as the tumor’s unique “fingerprints.” They’re specific genes, proteins, or molecules that can guide therapy choices (American Society of Clinical Oncology).
Next-Generation Sequencing (NGS)
This is the tech behind the scenes, reading the tumor’s DNA code quickly and accurately (Annals of Oncology).
Precision Medicine = Personalized Medicine
This is all about using the results of molecular profiling to tailor treatments specifically for your tumor (Frontiers in Oncology).
Targeted Therapy
These treatments go after specific genetic changes found through molecular profiling, offering a more focused approach than traditional chemo (Journal of Clinical Oncology).
Why Somatic Testing Matters for Pancreatic Cancer Patients
Pancreatic cancer moves fast. The right, targeted treatment at the right time can make all the difference. Somatic testing gives your oncologist a detailed genetic profile of your tumor, which can lead to:
• Personalized Treatment Plans: Therapies tailored to your tumor’s specific genetic changes (Cancer Discovery study).
• Biomarker Identification: Key features that can predict how well certain therapies might work (Pancreatic Cancer Action Network).
• Better Survival Rates: Research shows patients with therapies matched to their somatic test results do better overall (Journal of Clinical Oncology).
• Access to Clinical Trials: Discovering genetic mutations might open the door to cutting-edge trials (Clinical Cancer Research).
Your Options and Things to Consider
While the FoundationOne® CDx test is a well-known option, it’s just one of many reputable providers. Heather went through two rounds of somatic testing, highlighting its importance. That said, we can’t tell you which test is best—that’s a conversation for you and your oncologist (Annals of Oncology).
Heather’s first provider went bankrupt, which caused a lot of stress. We suggest choosing a lab with a strong reputation to avoid these pitfalls.
PanCAN’s Know Your Tumor Service: A Free, Comprehensive Option
One valuable option is the Know Your Tumor service from PanCAN, which offers somatic testing at no cost. This service analyzes both the tumor’s genetic profile and inherited mutations, giving personalized treatment advice (PanCAN Know Your Tumor).
If paying out of pocket isn’t possible, this program can be a great resource. And even Pancreatic Cancer Canada recommends reaching out to PanCAN. If money isn’t a barrier, you can bypass red tape and contact FoundationOne® CDx directly, but keep in mind the cost may exceed $3,000 CAD.
What to Expect During Somatic Testing
Don’t not wait—have a conversation with your oncologist as soon as possible about somatic testing. Here’s what typically happens once you decide to proceed:
1. Sample Preparation: The lab prepares your tumor tissue sample, checking its quality.
2. Genomic Sequencing: Using NGS, the lab reads the DNA to identify mutations and biomarkers (Foundation Medicine).
3. Data Interpretation: You’ll get a detailed report with key findings and potential treatment options.
Turnaround Times
Keep in mind that turnaround times vary depending on the lab and specific test. It’s a good idea to ask your oncologist what to expect.
Biomarkers and Precision Medicine
Biomarkers give us clues about how your cancer might respond to certain treatments. Somatic testing helps identify these features, guiding oncologists in choosing therapies. For instance, mutations in KRAS or BRCA genes can influence your treatment plan (Nature Reviews Cancer).
Wrapping Up: Why It All Matters
Somatic testing is a powerful tool in the fight against pancreatic cancer, offering insights that can lead to personalized treatments and better outcomes. Understanding the genetic profile of your tumor can help you and your care team explore more effective therapies and clinical trials. If you haven’t yet, don’t overlook PanCAN’s Know Your Tumor service—it’s free, comprehensive, and can make a big difference.
For more about the differences between somatic and genetic testing, check out our detailed guide in Introduction to Advocacy Part Three.